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Total 41986 results found since Jan 2013.

Serum and Bronchoalveolar Lavage Fluid 25(OH)Vitamin D3 Levels in HIV-1 and Tuberculosis: A Cross-Sectional Study from a Tertiary Care Center in North India.
CONCLUSION: Lower levels of serum and BALF 25D3 were observed in HIV, TB, and HIV-TB coinfected patients. Localized deficiency of vitamin D metabolites might be associated with increased vulnerability to TB infection. PMID: 29807518 [PubMed - as supplied by publisher]
Source: Current HIV Research - May 27, 2018 Category: Infectious Diseases Authors: Sinha S, Gupta K, Mandal D, Das BK, Pandey RM Tags: Curr HIV Res Source Type: research

Vitamin D and bone loss in HIV
Purpose of review: Bone health has become an increasingly important aspect of the care of HIV-infected patients as bone loss with antiretroviral therapy (ART) initiation is significant and osteopenia and osteoporosis are highly prevalent. Vitamin D is tightly linked to calcium balance and bone health, and vitamin D deficiency is common in HIV. This review outlines the epidemiology of vitamin D deficiency in HIV, summarizes our current understanding of the relationship between vitamin D and bone loss in HIV and the impact of vitamin D supplementation in this patient group. Recent findings: Although data are conflicting as ...
Source: Current Opinion in HIV and AIDS - April 8, 2016 Category: Infectious Diseases Tags: BONE COMPLICATIONS IN HIV: Edited by Patrick W.G. Mallon and Todd T. Brown Source Type: research

Outcomes In Older Versus Younger Patients Over 96 Weeks In Hiv-1-Infected Patients Treated With Rilpivirine Or Efavirenz In Echo And Thrive.
Conclusion: Efficacy and safety outcomes were generally similar in older versus younger patients in the ECHO and THRIVE trials. PMID: 24467642 [PubMed - as supplied by publisher]
Source: Current HIV Research - January 28, 2014 Category: Infectious Diseases Authors: Ryan R, Dayaram YK, Schaible D, Coate B, Anderson D Tags: Curr HIV Res Source Type: research

Update on the key developments of the neurologic complications in children infected with HIV
Purpose of review: To discuss recent research findings of neurologic complications in HIV-infected children, specifically addressing neuroinfections, cerebrovascular disease, epilepsy and neurocognitive complications. The range of neurologic childhood onset complications is diverse and often overlaps diseases previously considered only to manifest in adults. In the pediatric population, these complications frequently have their own unique disease identity, which may be related to maturational patterns evident in the developing brain. Recent findings: Developments regarding the pathogenesis of neuroAIDS, treatment of tuberc...
Source: Current Opinion in HIV and AIDS - October 6, 2014 Category: Infectious Diseases Tags: HIV NEUROLOGY: Edited by Christopher Power and Bruce J. Brew Source Type: research

Noncommunicable diseases in adolescents with perinatally acquired HIV-1 infection in high-income and low-income settings
Purpose of review Perinatally HIV-infected adolescents may be at increased risk of noninfectious comorbidities later in life. This review summarizes recent advances in the understanding of noncommunicable diseases (NCD) among HIV-infected adolescents in high-income and lower middle-income countries, and identifies key questions that remain unanswered. We review atherosclerotic vascular disease (AVD), chronic bone disease (CBD), chronic kidney disease (CKD), and chronic lung disease (CLD). Recent findings Persistent immune activation and inflammation underlie the pathogenesis of AVD, highlighting the importance of trea...
Source: Current Opinion in HIV and AIDS - May 1, 2018 Category: Infectious Diseases Tags: ADOLESCENTS AND HIV: Edited by Mary-Ann Davies and Elizabeth Hamlyn Source Type: research

Vitamin D and Calcium Supplement Attenuate Bone Loss among HIV-infected Patients Receiving Tenofovir Disoproxil Fumarate/Emtricitabine/Efavirenz: An Open-label, randomized Controlled Trial.
CONCLUSION: Vitamin D2 and calcium supplements should be considered for HIV-infected patients receiving TDF/FTC/EFV in a resource-limited setting where there are limited ART options (Clinicaltrials.gov NCT0287643). PMID: 31906840 [PubMed - as supplied by publisher]
Source: Current HIV Research - January 5, 2020 Category: Infectious Diseases Authors: Boontanondha P, Nimitphong H, Musikarat S, Ragkho A, Kiertiburanakul S Tags: Curr HIV Res Source Type: research

Co-medications and drug-drug interactions in people living with HIV in Turkey in the era of integrase inhibitors.
CONCLUSION: Results suggested the need for attention about co-medication in PLWH regardless of whether they are young or older. CNS drugs should be questioned more detailed in MSM, as well as CVS drugs in older HS patients. Elvitegravir/cobicistat is significantly associated with DDIs and switching to an unboosted INSTI should be considered in patients with multiple comorbidities. PMID: 32787762 [PubMed - as supplied by publisher]
Source: Current HIV Research - August 11, 2020 Category: Infectious Diseases Authors: Yeşilbağ Z, Şengül Eİ, Şenoğlu S, Aydın ÖA, Karaosmanoğlu HK Tags: Curr HIV Res Source Type: research

Assessing changes in vitamin D over 48 weeks in treatment-na ïve HIV individuals starting lopinavir/ritonavir monotherapy.
CONCLUSION: Individuals treated with lopinavir/ritonavir monotherapy had significantly higher 25(OH)D after 48 weeks. Current tobacco users had significantly diminished CD4 cell count recovery after starting treatment, warranting further clinical investigation. PMID: 32860360 [PubMed - as supplied by publisher]
Source: Current HIV Research - August 26, 2020 Category: Infectious Diseases Authors: Crutchley RD, Jacobs DM, Gathe J, Mayberry C, Bulayeva N, Rosenblatt KP, Garey KW Tags: Curr HIV Res Source Type: research

Low Vitamin D Predicts Death in HIV-PositiveLow Vitamin D Predicts Death in HIV-Positive
Current vitamin D levels are associated with increased mortality in HIV-infected patients. Certain inflammatory markers also predict death, say researchers. Medscape Medical News
Source: Medscape Hiv-Aids Headlines - November 19, 2013 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news

Naringin Ameliorates HIV-1 Nucleoside Reverse Transcriptase Inhibitors-Induced Mitochondrial Toxicity.
CONCLUSION: Naringin ameliorated oxidative stress and NRTI-induced mitochondrial damage and might, therefore, be beneficial in managing toxicities and complications arising from NRTI use. PMID: 27197616 [PubMed - as supplied by publisher]
Source: Current HIV Research - May 19, 2016 Category: Infectious Diseases Authors: Oluwafeyisetan A, Olubunmi A, Peter O Tags: Curr HIV Res Source Type: research

Statin-Associated Myalgia and Vitamin D Deficiency in HIV Statin-Associated Myalgia and Vitamin D Deficiency in HIV
A new study explores the connection between vitamin D deficiency and the risk for statin-related myalgia among HIV patients receiving antiretroviral therapy.AIDS
Source: Medscape Hiv-Aids Headlines - April 6, 2017 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

High-Dose Vitamin D for Bone Health in HIV-Infected Young Adults High-Dose Vitamin D for Bone Health in HIV-Infected Young Adults
Markers of bone health in HIV-infected patients age 18 to 25 with vitamin D deficiency improve after 12 months of high-dose supplementation, a new clinical trial shows.Reuters Health Information
Source: Medscape Hiv-Aids Headlines - October 3, 2017 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news

Pharmacologic approaches to the prevention and management of low bone mineral density in HIV-infected patients
Purpose of review: Osteoporosis is a growing concern among people living with HIV (PLWH) because of the recognized risk of fractures, which bring with them morbidity and mortality. New evidence is helping clinicians understand how to prevent and manage osteoporosis in this subpopulation. Recent findings: The benefit of calcium and vitamin D is variable in osteoporosis literature in general, but evidence supports the use of these supplements in PLWH to prevent the loss of bone mineral density when initiating antiretroviral therapy and in enhancing the effectiveness of antiosteoporosis treatments. Of the osteoporosis treatm...
Source: Current Opinion in HIV and AIDS - April 8, 2016 Category: Infectious Diseases Tags: BONE COMPLICATIONS IN HIV: Edited by Patrick W.G. Mallon and Todd T. Brown Source Type: research

Lower-extremity Dynamometry as a Novel Outcome Measure in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy
Conclusion: We conclude that an adequately powered clinical trial of IVIG for HIVM would likely require a prolonged recruitment period and multiple participating sites. Lower limb dynamometry is a useful outcome measure for HIVM, which might also be useful in other HIV-related gait disorders. KEYWORDS: Dynamometry, intravenous immunoglobulin (IVIG), human immunodeficiency virus (HIV), myelopathy INTRODUCTION Human immunodeficiency virus (HIV)-associated myelopathy (HIVM) is a rare but well-described neurologic complication of HIV; it was first described early in the acquired immunodeficiency syndrome (AIDS) epidemic, and i...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools Current Issue Demyelinating Disease Movement Disorders Neurodegenerative Disease Neurology Original Research Primary Care Technology Trial Methodology Dynamometry human immunodeficiency virus (HIV) intravenous immu Source Type: research

Tropical Travel Trouble 009 Humongous HIV Extravaganza
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with a low ...
Source: Life in the Fast Lane - July 7, 2018 Category: Emergency Medicine Authors: Amanda McConnell Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs